Garcinia Cambogia (hydroxycitric acid) for Weight Loss – Efficacy and Side Effects
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According to Dr. Oz Garcinia Cambogia is:
“Revolutionary new research says it could be the magic ingredient that lets you lose weight without diet and exercise” - Dr.Oz
But should we believe all the hype? Sorry, not to rain on the parade, but I’m a skeptic (and so is the research).
- Journal of Obesity: The evidence from RCTs suggests that Garcinia extracts/HCA generate weight loss on the short term. However, the magnitude of this effect is small, is no longer statistically significant when only rigorous RCTs are considered, and its clinical relevance seems questionable. Future trials should be more rigorous, longer in duration, and better reported.
- An overview of the safety and efficacy of a novel, natural hydroxycitric acid extract (HCA-SX) for weight management: At the end of 8 weeks, body weight and BMI decreased by 5.4% and 5.2%, respectively. Study include 30 minute walking program and only 60 volunteers.
- Garcinia cambogia as a potential antiobesity agent: a randomized controlled trial: Garcinia cambogia failed to produce significant weight loss and fat mass loss beyond that observed with placebo
- Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humans: at the doses usually administered, no differences have been reported in terms of side effects or adverse events (those studied) in humans between individuals treated with G. cambogia and controls.
- NIH Report: Although studies supporting its use have been published, no information supporting the safety of this product was identified in the available literature.
Information and Education
|Based on The Natural Medicines Comprehensive Database|
|What is it?|
|Garcinia is a plant. The fruit rind is used to make medicine. Don’t confuse garcinia with Garcinia hanburyi (gamboge resin).|
|Is it Effective?|
|Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.The effectiveness ratings for GARCINIA are as follows:|
|Possibly Ineffective for…|
- Weight loss. Taking garcinia fruit rind extract doesn’t seem to decrease weight, fat breakdown, or energy expenditure in overweight people. There is some mixed evidence that garcinia might help people feel full even when eating less, but it’s too early to recommend garcinia for this use.
|Insufficient Evidence to Rate Effectiveness for…|
- Treating worms and parasites.
- Emptying the bowel.
- Severe diarrhea (dysentery).
- Other conditions.
More evidence is needed to rate the effectiveness of garcinia for these uses.
|How does it work?|
|Developing research suggests that garcinia might prevent fat storage and control appetite; however, whether these effects occur in humans is unclear.Mechanism of Action: The applicable parts of garcinia are the fruit and rind. Garcinia fruit rind extract, reported to contain 50% hydroxycitric acid (HCA), is theorized to interfere with lipogenesis. The active ingredient HCA is believed to be a competitive inhibitor of ATP-citrate-lyase, the enzyme responsible for converting citrate into acetyl-coenzyme A (acetyl-CoA). This conversion into acetyl-CoA occurs when the energy consumed exceeds the energy requirements of the body. Other researchers think that garcinia inhibits the supply of fatty acids without affecting adipose conversion. Preliminary research suggests that garcinia inhibits the accumulation of lipid droplets in fat cells and thereby reduces lipid levels and decreases lipid accumulation in the liver (8571). The HCA found in garcinia is also theorized to improve exercise endurance by increasing lipid oxidation and decreasing carbohydrate utilization. Some animal research suggests that HCA might suppress appetite.|
|Are there safety concerns?|
|Garcinia is POSSIBLY SAFE for most people when used for 12 weeks or less. Long-term safety is unknown. Garcinia can cause nausea, digestive tract discomfort, and headache.|
Special Precautions & Warnings:
Pregnancy and breast-feeding: Not enough is known about the use of garcinia during pregnancy and breast-feeding. Stay on the safe side and avoid use.
|Are there any interactions with medications?|
|It is not known if this product interacts with any medicines.Before taking this product, talk with your health professional if you take any medications.|
|Are there any interactions with Herbs and Supplements?|
|There are no known interactions with herbs and supplements.|
|Are there interactions with Foods?|
|There are no known interactions with foods.|
|What dose is used?|
|The appropriate dose of garcinia depends on several factors such as the user’s age, health, and several other conditions. At this time, there is not enough scientific information to determine an appropriate range of doses for garcinia. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.|
|What other names is the product known by?|
|Acide Hydroxycitrique, AHC, Brindal Berry, Brindle Berry, Cambogia gummi-guta, Garcinia Cambogi, Garcinia cambogia, Garcinia gummi-guta, Garcinia quaesita, Gorikapuli, Hydroxycitrate, Hydroxycitric Acid, HCA, Kankusta, Malabar Tamarind, Mangostana cambogia, Tamarinier de Malabar, Vrikshamla.|