Garlic Extract (ALLICIN POTENTIAL): The Second “G” in PAGG

Note: The World Health Organization (WHO) 1999 monograph recommends 2-5 g of fresh garlic, 0.4-1.2 g of dried powder, 2-5 mg of oil, 300-1000 mg of extract, or other formulations corresponding to 2-5 mg allicin

Garlic Extract shows up in the 4-Hour Body as part of PAGG

In the 4 Hour Body Tim Claims:

“Allicin, if delivered in a stable form, appears to have the ability to inhibit fat regain”

The Four Horsemen of Fat-Loss: PAGG

Daily PAGG intake is timed before meals and bed, which produces a schedule like this: (AGG is simply PAGG minus policosanol)

  • Prior to breakfast: AGG
  • Prior to lunch: AGG
  • Prior to dinner: AGG
  • Prior to bed: PAG (omit the green tea extract)

This dosing schedule is followed six days a week. Take one day off each week and one week off every two months.

You can also purchase this as a Combo Through Pareto Nutrition Here (not ranked on the Natural Medicines Database)


What is it?

Garlic is an herb. It is best known as a flavoring for food. But over the years, garlic has been used as a medicine to prevent or treat a wide range of diseases and conditions. The fresh clove or supplements made from the clove are used for medicine.

Garlic is used for many conditions related to the heart and blood system. These conditions include high blood pressure, high cholesterol, coronary heart disease, heart attack, and “hardening of the arteries” (atherosclerosis). Some of these uses are supported by science. Garlic actually may be effective in slowing the development of atherosclerosis and seems to be able to modestly reduce blood pressure.

Some people use garlic to prevent colon cancer, rectal cancer, stomach cancer, breast cancer, prostate cancer, and lung cancer. It is also used to treat prostate cancer and bladder cancer.

Garlic has been tried for treating an enlarged prostate (benign prostatic hyperplasia; BPH), diabetes, osteoarthritis, hayfever (allergic rhinitis), traveler’s diarrhea, high blood pressure late in pregnancy (pre-eclampsia), cold and flu. It is also used for building the immune system, preventing tick bites, and preventing and treating bacterial and fungal infections.

Other uses include treatment of fever, coughs, headache, stomach ache, sinus congestion, gout, rheumatism, hemorrhoids, asthma, bronchitis, shortness of breath, low blood pressure, low blood sugar, high blood sugar, and snakebites. It is also used for fighting stress and fatigue, and maintaining healthy liver function.

Some people apply garlic oil to their skin to treat fungal infections, warts, and corns. There is some evidence supporting the topical use of garlic for fungal infections like ringworm, jock itch, and athlete’s foot; but the effectiveness of garlic against warts and corns is still uncertain.

There is a lot of variation among garlic products sold for medicinal purposes. The amount of allicin, the active ingredient and the source of garlic’s distinctive odor, depends on the method of preparation. Allicin is unstable, and changes into a different chemical rather quickly. Some manufacturers take advantage of this by aging garlic to make it odorless. Unfortunately, this also reduces the amount of allicin and compromises the effectiveness of the product. Some odorless garlic preparations and products may contain very little, if any, allicin. Methods that involve crushing the fresh clove release more allicin. Some products have a coating (enteric coating) to protect them against attack by stomach acids.

While garlic is a common flavoring in food, some scientists have suggested that it might have a role as a food additive to prevent food poisoning. There is some evidence that fresh garlic, but not aged garlic, can kill certain bacteria such as E. coli, antibiotic-resistant Staphylococcus aureus, and Salmonella enteritidis in the laboratory.

Is it Effective?

The effectiveness ratings for GARLIC are as follows:

Possibly Effective for…

  • High blood pressure. Some research shows that garlic can reduce blood pressure in people with high blood pressure by as much as 7% or 8%. It also seems to lower blood pressure in people with normal blood pressure. Most studies have used a specific garlic powder product (Kwai, from Lichtwer Pharma).
  • “Hardening of the arteries” (atherosclerosis). As people age, their arteries tend to lose their ability to stretch and flex with age. Garlic seems to reduce this effect.
  • Colon cancer, rectal cancer, and stomach cancer. Eating garlic seems to reduce the risk of developing these cancers. However, garlic supplements don’t seem to offer the same benefit.
  • Tick bites. Scientists have compared the number of tick bites in people who take high doses of garlic compared to people who do not take garlic. High doses of dietary garlic, over about a five-month period, seem to reduce the number of tick bites.
  • Fungal infections of the skin (including ringworm, jock itch and athlete’s foot). Ringworm and jock itch respond to treatment with a garlic gel containing 0.6% ajoene (a chemical in garlic) that is applied to the skin. A garlic gel with a higher concentration of ajoene (1%) is needed to be effective against athlete’s foot. In fact, garlic gel with 1% ajoene seems to be about as effective against athlete’s foot as the medicine Lamisil.

Possibly Ineffective for…

  • Diabetes. Taking garlic doesn’t seem to have any effect on blood sugar, either in people with diabetes or those without it.
  • Treating bacteria called helicobacter pylori (H. pylori) that can cause ulcers. Taking garlic by mouth for H. pylori infection used to look promising due to laboratory evidence showing potential activity against H. pylori. However, when garlic cloves, powder, or oil is used in humans, it doesn’t seem to have any beneficial effect for treating people infected with H. pylori.
  • High cholesterol. Lots of studies — some better than others — have been done to measure the effectiveness of garlic in lowering cholesterol and another type of fat called triglycerides. The results have been conflicting. However, if only the high quality studies are considered, reviewers conclude that garlic does not significantly lower cholesterol or triglyceride levels.
  • Breast cancer. Taking garlic does not seem to reduce the risk of getting breast cancer.
  • Lung cancer. Taking garlic does not seem to reduce the risk of getting lung cancer.
  • Leg pain when walking due to poor blood circulation in the legs (peripheral arterial disease or PAD). Taking garlic, even for 12 weeks, does not seem to help people with this condition.

Insufficient Evidence to Rate Effectiveness for…

  • Benign prostatic hyperplasia (BPH). There is some preliminary evidence that taking garlic by mouth might be helpful for improving urinary flow, decreasing urinary frequency, and other symptoms associated with BPH.
  • Common cold. Preliminary research suggests garlic might reduce the frequency and number of colds when taken for prevention.
  • Corns. Early studies suggest that applying certain garlic extracts to corns on the feet twice daily improves corns. One particular garlic extract that dissolves in fat has an effect after 10-20 days of treatment, but a water soluble extract can take up to two months to show improvement.
  • High blood pressure in pregnancy (pre-eclampsia). Some preliminary clinical evidence suggests that taking a specific garlic extract (Garlet) 800 mg/day during the third trimester of pregnancy does not reduce the risk of developing pre-eclampsia in high-risk women.
  • Prostate cancer. Men in China who eat about a clove of garlic daily seem to have a 50% lower risk of developing prostate cancer. Whether this benefit applies to men in Western countries is not known.
  • Warts. Preliminary evidence suggests that applying a specific fat soluble garlic to warts on the hands twice daily removes warts within 1-2 weeks. A water-soluble garlic extract also seems to provide modest improvement, but only after 30-40 days of treatment.

More evidence is needed to rate garlic for these uses.

How does it work?

Garlic produces a chemical called allicin. This is what seems to make garlic work for certain conditions. Allicin also makes garlic smell. Some products are made “odorless” by aging the garlic, but this process can also make the garlic less effective. It’s a good idea to look for supplements that are coated (enteric coating) so they will dissolve in the intestine and not in the stomach.

Are there safety concerns?

Garlic is LIKELY SAFE for most people when taken by mouth. Garlic can cause bad breath, a burning sensation in the mouth or stomach, heartburn, gas, nausea, vomiting, body odor, and diarrhea. These side effects are often worse with raw garlic. Garlic may also increase the risk of bleeding. There have been reports of bleeding after surgery in people who have taken garlic. Asthma has been reported in people working with garlic, and other allergic reactions are possible.
When used on the skin, garlic is POSSIBLY UNSAFE. Using as a thick paste (poultice), garlic can cause damage to the skin that is similar to a burn.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Garlic is LIKELY SAFE in pregnancy when taken in the amounts normally found in food. Garlic is POSSIBLY UNSAFE when used in medicinal amounts in pregnancy and breast-feeding. There isn’t enough reliable information about the safety of using garlic on the skin if you are pregnant or breast-feeding. Stay on the safe side, and avoid use.
Children: Garlic is POSSIBLY SAFE when taken by mouth and appropriately for a short-term in children. But garlic is POSSIBLY UNSAFE when taken by mouth in large doses. Some sources suggest that high doses of garlic could be dangerous or even fatal to children; however, the reason for this warning is not known. There are no case reports available of significant adverse events or mortality in children associated with taking garlic by mouth.
Bleeding disorder: Garlic, especially fresh garlic, might increase bleeding.
Stomach or digestion problems: Garlic can irritate the gastrointestinal (GI) tract. Use with caution if you have stomach or digestion problems.
Surgery: Garlic might prolong bleeding. Stop taking garlic at least two weeks before a scheduled surgery.

Are there any interactions with medications?

Birth control pills (Contraceptive drugs)
Interaction Rating = Moderate Be cautious with this combination.
Talk with your health provider.

Some birth control pills contain estrogen. The body breaks down the estrogen in birth control pills to get rid of it. Garlic might increase the breakdown of estrogen. Taking garlic along with birth control pills might decrease the effectiveness of birth control pills. If you take birth control pills along with garlic, use an additional form of birth control such as a condom.
Some birth control pills include ethinyl estradiol and levonorgestrel (Triphasil), ethinyl estradiol and norethindrone (Ortho-Novum 1/35, Ortho-Novum 7/7/7), and others.

Cyclosporine (Neoral, Sandimmune)
Interaction Rating = Moderate Be cautious with this combination.
Talk with your health provider.

The affect of garlic preparations on cyclosporine may vary. Some garlic preparations containing allicin might decrease the effectiveness of cyclosporine. However, other garlic preparations containing alliin and alliinase may not. Until more is known about this possible interaction, don’t take garlic if you are taking cyclosporine.

Isoniazid (INH, Nydrazid)
Interaction Rating = Major Do not take this combination.

Garlic might reduce how much isoniazid (Nydrazid, INH) the body absorbs. This might decrease how well isoniazid (Nydrazid, INH) works. Don’t take garlic if you take isoniazid (Nydrazid, INH).

Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates)
Interaction Rating = Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. Garlic oil might decrease how quickly the liver breaks down some medications. Taking garlic oil along with some medications that are changed by the liver can increase the effects and side effects of your medication. Before taking garlic oil, talk to your healthcare provider if you take any medications that are changed by the liver.
Some medications that are changed by the liver include acetaminophen, chlorzoxazone (Parafon Forte), ethanol, theophylline, and drugs used for anesthesia during surgery such as enflurane (Ethrane), halothane (Fluothane), isoflurane (Forane), and methoxyflurane (Penthrane).

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Interaction Rating = Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. Garlic might increase how quickly the liver breaks down some medications. Taking garlic along with some medications that are broken down by the liver can decrease the effectiveness of some medications. Before taking garlic, talk to your healthcare provider if you are taking any medications that are changed by the liver.
Medications that might be affected include certain heart medications called calcium channel blockers (diltiazem, nicardipine, verapamil), cancer drugs (etoposide, paclitaxel, vinblastine, vincristine, vindesine), fungus-fighting drugs (ketoconazole, itraconazole), glucocorticoids, alfentanil (Alfenta), cisapride (Propulsid), fentanyl (Sublimaze), lidocaine (Xylocaine), losartan (Cozaar), midazolam (Versed), and others.

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating = Moderate Be cautious with this combination.
Talk with your health provider.

Garlic might slow blood clotting. Taking garlic along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Medications used for HIV/AIDS (Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs))
Interaction Rating = Major Do not take this combination.

The body breaks down medications used for HIV/AIDS to get rid of them. Garlic can increase how fast the body breaks down some medications for HIV/AIDS. Taking garlic along with some medications used for HIV/AIDS might decrease their effectiveness.
Some of these medications used for HIV/AIDS include nevirapine (Viramune), delavirdine (Rescriptor), and efavirenz (Sustiva).

Saquinavir (Fortovase, Invirase)
Interaction Rating = Major Do not take this combination.

The body breaks down saquinavir (Fortovase, Invirase) to get rid of it. Garlic might increase how quickly the body breaks down saquinavir. Taking garlic along with saquinavir (Fortovase, Invirase) might decrease the effectiveness of saquinavir (Fortovase, Invirase).

Warfarin (Coumadin)
Interaction Rating = Moderate Be cautious with this combination.
Talk with your health provider.

Warfarin (Coumadin) is used to slow blood clotting. Garlic might increase the effectiveness of warfarin (Coumadin). Taking garlic along with warfarin (Coumadin) might increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.

Are there any interactions with Herbs and Supplements?

Fish oil (containing eicosapentaenoic acid (EPA))

Fish oil can slow blood clotting. Garlic can also slow clotting. Taken together, garlic and fish oil may increase the risk of bleeding in some people.

Herbs and supplements that might slow blood clotting

Using garlic with other herbs that can slow blood clotting might increase the risk of bleeding in some people. These other herbs include angelica, clove, danshen, ginger, ginkgo, red clover, turmeric, vitamin E, willow, and others.

Are there interactions with Foods?

There are no known interactions with foods.

What dose is used?

The following doses have been studied in scientific research:

  • For high blood pressure:
    • Garlic extract 600-1200 mg divided and given three times daily.
    • Standardized garlic powder extract containing 1.3% alliin content has been studied for this use.
    • Aged garlic extract 600 mg to 7.2 grams per day has also been used. Aged garlic typically contains only 0.03% alliin.
    • Fresh garlic 4 grams (approximately one clove) once daily has also been used. Fresh garlic typically contains 1% alliin.
  • For prevention of colon, rectal, and stomach cancer: fresh or cooked garlic 3.5-29 grams weekly.


  • For fungal skin infections (ringworm, jock itch, athlete’s foot): garlic ingredient ajoene as a 0.4% cream, 0.6% gel, and 1% gel applied twice daily for one week.

What other names is the product known by?

Aged Garlic Extract, Ail, Ajo, Allii Sativi Bulbus, Allium, Allium sativum, Camphor of the Poor, Clove Garlic, Da Suan, Garlic Clove, Garlic Oil, Lasun, Lasuna, Nectar of the Gods, Poor Man’s Treacle, Rason, Rust Treacle, Stinking Rose.

Provided by
Based on
Natural Medicines Comprehensive Database

From The 4-Hour Body


Garlic extract and its constituent parts have been used for applications ranging from cholesterol management to inhibiting lethal MRSA staph infections. Strangely, test subjects and I have had the best fat-loss results with extracts designed to deliver relatively high doses of allicin.  Allicin, if delivered in a stable form, appears to have the ability to inhibit fat regain. The reason our results were “strange” relates to the “stable form” bit.  Most research indicates that allicin should have almost zero bioavailability more than six days after extraction from garlic cloves, particularly after exposure to stomach acid. Our confounding results could be due to a combination of other organic components, most notably one precursor to allicin: S-Allyl cysteine (alliin). S-Allyl cysteine exhibits outstanding oral bioavailability, near 100% in large mammals. Until further research concludes otherwise, I suggest using an aged-garlic extract (AGE) with high allicin potential that includes all constituent parts, including S-Allyl cysteine.  If AGE isn’t available, unaged garlic extract appears to work at slightly higher doses. I’ve tried consuming it fresh, chomping on cloves, and it isn’t kind to your digestive tract. If you are going the whole-food route, use it in your cooking to prevent stomach self-destruction. For precision and convenience, I use supplements to reach my target baseline in dosing, and I use extra garlic in food for delectable (but not necessary) insurance above that baseline.

Ferriss, Timothy (2010). The 4-Hour Body


Nature’s Way Garlicin Enteric Coated Odor Free Tabs  (brand recommended by Tim from the 4-Hour Body)

Garlicin 4-Hour Body

Natural Medicines Brand Evidence-based Rating (NMBER)

Natural Medicines Brand Evidence-based Rating (NMBER)=6

Each tablet contains: Garlic bulb powder (providing allicin 3200 mcg) 350 mg. Other Ingredients: Cellulose, Aqueous Coating Solution, Xylitol, Modified Cellulose Gum, Stearic Acid, Silica.

{ 15 comments… read them below or add one }

lou March 1, 2012 at 11:11 am

Hi Stephen,
Looking for clarification please.
“aging garlic to make it odorless. Unfortunately, this also reduces the amount of allicin and compromises the effectiveness of the product. Some odorless garlic preparations and products may contain very little, if any, allicin.” (What Is It section)
“I suggest using an aged-garlic extract (AGE) with high allicin potential that includes all constituent parts, including S-Allyl cysteine.” (4HB)
Confusing. I bought an Aged Garlic Extract that has 300mg of Allium sativum – it doesn’t say anything about allicin potential. Can I use this or do I need to look for Allicin specifically.
(great site btw)


Stephen April 15, 2012 at 6:11 pm

Hi lou,

I had meant to write you back long ago, I apologize for the extremely late reply. You bring up a great point and I had to do a bit of research. I am a big fan of Kyolic brand and they actually touched on your question within a Q&A on their website:

As well as this wonderful discussion about Allicin specifically:

I wen’t ahead and contacted corporate with your exact question… I will notify you when I get a reply.


Karolina January 15, 2013 at 12:36 pm

Hi Stephen,

I’m even more confused after checking out the second link you mentioned in your post. If allicin is so good how to explain the following (from the above mentioned website): “Allicin is a harsh oxidizing agent and high amounts have been shown to aggravate the intestinal lining as well as the stomach.
— if the allicin is absorbed by the liver in small amounts, it is completely metabolized or detoxified, however, absorbed in large amounts it may damage liver tissue.
— if it makes it past the liver to the blood, it may oxidize red blood cells.”

Oxidizing? So after taking garlic I need to make sure I take a bunch of anti-oxidants?? This is just aside from the fact that it may damage the liver and kills good bacteria as well…Anyway, the real question is if Allicin is really safe or not.

In response to Lou’s post, I found a product that contains allicin. in fact they specifically say on the box the following: ” Contains Allicin, Not Found in Aged Garlic”. more info on this webiste: (“”)
I got mine from Whole Foods but now I’m concerned if this Allicin is a good thing at all . If anyone came across some good studies and research papers on this, do share.


Galia May 14, 2013 at 2:46 am

Hi Stephen,

I want to take the prescribed 200mg of garlic extract Tim recommends in his book. However he also mentions that you can choose to go the whole food route. In that case how many garlic cloves would I need to consume to get equivalent of 200mg and does it need to be raw?

Thanks, (I can’t find this info. in the book and nowhere online either!)


Stephen May 18, 2013 at 8:11 am

This is a great question. One clove of garlic is roughly 3 grams or roughly 3000 mg. I am not sure if this is a 1:1 conversion. This is what I found using a quick internet search:

Unless otherwise prescribed, an average daily dose is:
– 2-5 g fresh garlic ( 1-4 cloves)
– Dried powder: 0.4-1.2 g
– Oil: 2-5 mg
– Extract: 300-1000 mg (solid)
– Other preparations: equivalent of 2-5 mg alliicin.


Eda July 24, 2013 at 3:56 pm


Could you tell me if Garlic Ajoene 1% gel is available on market?



Stephen July 26, 2013 at 3:18 pm

Hi Eda, I am not familiar with that specific product. But the Internets are sure to have almost anything your heart desires.

Best of luck,



Jason October 29, 2013 at 11:13 am

Hey Stephen,

I’m a 4HB newbie. I thought Tim recommended the Vitamin Shoppe Allicin 6000 Garlic, 650 mg, 100 caplets? Did he change the recommendation to Nature’s Way based on findings? Maybe my 4 hour body book is an old version? Have any other of the PAGG supplement sources recommended in the original book changed since then?

Also, Tim recommends 325 mg for the EGCG and 200 mg for the Garlic but the Vitamin Shoppe Garlic comes in a 650 caplet and the EGCG brand he recommended comes in a 725 mg capsule. I had to take my full daily dosage for both this morning since I couldn’t break it up like a pill. How do people take the recommend dosage with these particular brands?





anil kumr koshal March 11, 2014 at 6:05 am

please sir sugest me to method for extraction of s-allyl-l-cysteine from garlic.

and class of s-allyl cysteine just like it is alkaloide or flavonoide


Hep Yo October 9, 2014 at 12:43 pm

The idea that “Allicin content” is crucial in Garlic products, is a classic example of misapplication of a simplification. We are increasingly seeing this, as modern life is involved with so many technical things.

These simplifications are needed to give average people a rough idea of what is going on. But what happens is that people then think they can come to conclusions based on these simplifications. Then Marketing people grab these simplifications and use them for their own unfounded conclusions. Since there is always a small print disclaimer like “These statements do not represent any medical facts”, then the Marketing people can jump to whatever unfounded conclusion they like.

From 2007, here is the specific science of what happens:


Shane May 17, 2015 at 11:55 pm

So Hep Yo, are you saying any garlic vitamin is sufficent, I have no clue. Thanks


Stephen May 18, 2015 at 6:48 pm

Hi Shane, not necessarily, not all vitamins are created equal. If you follow the links to the supplements in the article these are the supplements I would recommend, based on dose and the company track record. If these aren’t available in your region the best bet is go to a natural/whole foods store and speak with someone familiar with the supplements. They can be a huge help and will lead you in the right direction (most of the time).

– Stephen


Shane May 18, 2015 at 10:08 pm

Thanks :)


callie July 21, 2015 at 12:24 pm

So Im wondering if this is necessary in the stack if you have zero concerns about regaining fat. What do you think? Is there any benefit for actual fat loss?


Stephen July 24, 2015 at 12:39 am

Hi Callie,

I think this is the million dollar question. If you above at the list of evidence-based recommendations I am not sure there is enough data to support Allicin’s use in this manner. But who knows what doses or intervals were given in these studies, you may have to test your theory and see for yourself. Keep us updated.

– Stephen


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