RIBOSE – Usage, Efficacy, Side Effects and Drug Interactions

D-Ribose Featured in “The GNC Gourmet: The Fun of Multipurpose Ingredients
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Consumer Information and Education
Provided by
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Based on
Natural Medicines Comprehensive Database
puhdr logo RIBOSE   Usage, Efficacy, Side Effects and Drug Interactions

RIBOSE

What is it?
Ribose is a kind of sugar that is produced by the body. It is used as a medicine.Ribose is used to improve athletic performance and the ability to exercise by boosting muscle energy. It has also been used to improve symptoms of chronic fatigue syndrome (CFS), fibromyalgia, and coronary artery disease. Ribose has been used to prevent symptoms such as cramping, pain, and stiffness after exercise in people with an inherited disorder called myoadenylate deaminase deficiency (MAD) or AMP deaminase deficiency (AMPD deficiency). Ribose has also been used to improve exercise ability in people with another inherited disorder called McArdle’s disease.Healthcare providers sometimes give ribose intravenously (by IV) as part of an imaging procedure used to measure the extent of damaged heart muscle in people with coronary artery disease. Ribose has also been used intravenously in patients with MAD to prevent symptoms such as cramping, pain, and stiffness.
Is it Effective?
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.The effectiveness ratings for RIBOSE are as follows:

Possibly Effective for…

  • Decreased blood flow through the arteries in the heart (coronary artery disease). Taking ribose orally seems to be effective for improving the heart’s ability to manage low blood flow in people with coronary artery disease.
  • Myoadenylate deaminase deficiency (MAD). Taking ribose by mouth or intravenously seems to be effective for preventing symptoms such as cramping, pain, and stiffness after exercise in patients with MAD, also known as AMP deaminase deficiency (AMPD deficiency). One case report and a small research study suggest symptoms can be prevented by giving ribose before and during exercise.
Possibly Ineffective for…

  • Improving athletic performance.
Likely Ineffective for…

  • Improving exercise ability in McArdle’s disease (a genetic metabolic disorder).
Insufficient Evidence to Rate Effectiveness for…

  • Chronic fatigue syndrome (CFS). There is some evidence that taking a ribose supplement (CORvalen, Valen Labs) daily might improve energy, sleep, and sense of well-being in people with chronic fatigue syndrome.
  • Fibromyalgia. Some research suggests that taking a ribose supplement (CORvalen, Valen Labs) daily can improve energy, sleep, sense of well-being and decrease pain in patients with fibromyalgia.
  • Congestive heart failure (CHF). Developing research suggests that patients with congestive heart failure who take a ribose daily for 3 weeks have better heart function and improved quality of life.
  • Coronary artery bypass surgery. Early research shows that people who take a ribose supplement immediately before surgery have better heart function after surgery.
  • Other conditions.

More evidence is needed to rate the effectiveness of ribose for these uses.

How does it work?
Ribose is an energy source that the body makes from food. There is some evidence that supplemental ribose might prevent muscle fatigue in people with genetic disorders that prevent sufficient energy production by the body. It might provide extra energy to the heart during exercise in people with heart disease.
Are there safety concerns?
Ribose seems to be safe for most people when taken by mouth for short-term use or when given by a healthcare provider intravenously. It can cause some side effects including diarrhea, stomach discomfort, nausea, headache, and low blood sugar.There isn’t enough information about the safety of long-term use.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of ribose during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Diabetes: Ribose might lower blood sugar. When used along with diabetes medications that lower blood sugar, it might make blood sugar drop too low. It’s best not to use ribose if you have diabetes.

Low blood sugar (hypoglycemia): Ribose might lower blood sugar. If you already have blood sugar that is too low, don’t take ribose.

Surgery: Since ribose might lower blood sugar, there is a concern that it might interfere with blood sugar control during and after surgery.

Are there any interactions with medications?

Alcohol

Interaction Rating = Minor Be watchful with this combination.
Talk with your health provider.

Alcohol might decrease your blood sugar. Ribose might also decrease your blood sugar. Taking ribose along with alcohol might cause your blood sugar to go too low.

Aspirin

Interaction Rating = Minor Be watchful with this combination.
Talk with your health provider.

Ribose might decrease blood sugar. Large amounts of aspirin might also decrease blood sugar. Taking ribose along with large amounts of aspirin might cause your blood sugar to go too low. But this interaction probably isn’t a big concern for most people that take 81 mg of aspirin a day.

Choline magnesium trisalicylate (Trilisate)

Interaction Rating = Minor Be watchful with this combination.
Talk with your health provider.

Choline magnesium trisalicylate (Trilisate) might decrease your blood sugar. Ribose might also decrease blood sugar. Taking ribose along with choline magnesium trisalicylate (Trilisate) might cause your blood sugar to be too low. But it is not clear if this interaction is a big concern.

Insulin

Interaction Rating = Moderate Be cautious with this combination.
Talk with your health provider.

Ribose might decrease blood sugar. Insulin is also used to decrease blood sugar. Taking ribose along with insulin might cause your blood sugar to be too low. Monitor your blood sugar closely. The dose of your insulin might need to be changed.

Medications for diabetes (Antidiabetes drugs)

Interaction Rating = Moderate Be cautious with this combination.
Talk with your health provider.

Ribose might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking ribose along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (Diabeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Propranolol (Inderal)

Interaction Rating = Minor Be watchful with this combination.
Talk with your health provider.

Propranolol (Inderal) might decrease blood sugar. Ribose might also decrease blood sugar. Taking ribose along with propranolol (Inderal) might cause your blood sugar to go too low.

Salsalate (Disalcid)

Interaction Rating = Minor Be watchful with this combination.
Talk with your health provider.

Large amounts of salsalate (Disalcid) can cause blood sugar to become low. Taking salsalate along with ribose might cause blood sugar to become too low.

Are there any interactions with Herbs and Supplements?
There are no known interactions with herbs and supplements.
Are there interactions with Foods?
There are no known interactions with foods.
What dose is used?
The following doses have been studied in scientific research:BY MOUTH:

  • To improve the ability of people with coronary artery disease to exercise: 15 grams four times daily. Beginning 1 hour before exercise until the end of the exercise session, 3 grams every 10 minutes has been used to reduce muscle stiffness and cramps caused by exercising.
What other names is the product known by?
Beta-D-ribofuranose, D-ribosa, D-ribose, Ribosa.

Resources

D-Ribose

 RIBOSE   Usage, Efficacy, Side Effects and Drug Interactions

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